The monoalkyl ethylene glycol ethers have been shown to possess a wide spectrum of biological activity, with some variation in the range of effects and potency among the individual compounds. Michael E. Peterson DVM, MS, Patricia A. Talcott MS, DVM, PhD, DAVBT, in Small Animal Toxicology (Second Edition), 2006. A member of the “glycol ethers” group, 2-butoxyethanol is a primary ingredient in many all-purpose cleaners. It can harm the eyes, skin, kidneys, and blood. The myelosuppressive activity of chloramphenicol is usually ascribed to the parent compound, but the nitroso metabolite of chloramphenicol shows a far greater inhibitory effect in mouse hematopoietic culture assays. Among the first studies is that of Exon et al. Canada only allows this chemical’s use in non-aerosol cleaners up to 6 percent. Thus, the dietary iron enrichment may enhance the incidence and severity of estrogen-induced tumor induction (Wyllie and Liehr, 1998). EGME was teratogenic, embryotoxic, and fetotoxic in pregnant animals. It is thought that 2-butoxyethanol contributed to the significantly shorter lifespan of Exxon Valdez clean-up workers, which is why Corexit 9527, which also contains the chemical was banned in the United Kingdom. S. Othumpangat, V. Castranova, in Encyclopedia of Toxicology (Third Edition), 2014. The National Institute for Occupational Safety and Health evaluated the acute effects of inhalation of dispersant in rats on the respiratory, cardiovascular, and nervous systems as well as the immune effects of dermal exposure. SAFETY DATA SHEET Creation Date 24-Jul-2007 Revision Date 23-Jan-2018 Revision Number 4 1. We use cookies to help provide and enhance our service and tailor content and ads. The delegate's interim decision under regulation 42ZCZN of the Therapeutic Goods Regulations 1990 (the Regulations) is to amend the current Poisons Standard in relation to 2-butoxyethanol as follows: New text is shown as green, larger font, with a horizontal line above it. The applicant's reasons for the proposal were: 2-Butoxyethanol is in Schedule 6, Appendix E and Appendix F of the Poisons Standard as follows: 2-BUTOXYETHANOL and its ACETATES except in preparations containing 10 per cent or less of such substances. Glycols are associated with severe morbidity and an increased risk of death. Exposed test subjects (rats) developed tolerance to 2-butoxyethanol (haemolytic effects). Read more here. Ironically, chemotherapeutic and other toxic agents, particularly alkylating agents, may result in leukemia, which is likely linked to cytogenetic abnormalities, especially with the loss of part or all of a chromosome. Since it is significantly less toxic as compared to ethylene glycol, propylene glycol is the preferred antifreeze used in motor homes and recreational vehicles. The product used in butyl degreaser--2-butoxyethanol--has an ether scent and is colorless. Glycol ethers as a class are not acutely toxic by the oral route. The iron chelator phenanthroline suppressed the sodium chloride–enhanced gastric car-cinogenesis induced by N-methyl-N’-nitro-N-nitrosoguanidine in experiments on Wistar rats (Tatsuta et al., 2003). Until this is complete we can not claim that it is a disinfectant in Canada. Iron can also maintain the growth of malignant cells, as well as the growth of pathogens. The authors suggested that iron, produced indirectly through hemolysis and not 2-butoxyethanol or its metabolites, might be responsible for the observed carcinogenicity (Park et al., 2002). It is a colorless liquid with a sweet, ether-like odour. You may recognize it by its sweet, slightly floral scent. Despite numerous cellular defense mechanisms such as antioxidant enzymes and low molecular weight antioxidants such as GSH, hemolysis may result if these mechanisms are overwhelmed in red blood cells. 2-BUTOXYETHANOL and its ACETATES except in preparations containing 1020 per cent or less of such substances. It may be accidentally ingested, particularly by children as it tastes sweet, or intentionally ingested by adults as an ethanol substitute or to inflict self-harm. Mice were not affected. 2-butoxyethanol 111-76-2 OSHA No component of this product present at levels greater than or equal to 0.1% is on OSHA’s list of regulated carcinogens. The level of exposure depends upon the dose, duration, and work being done. McMartin, in Human Toxicology, 1996. 2-Butoxyethanol was identified as a causal agent in the health problems experienced by cleanup workers after the 1989 Exxon Valdez oil spill. 2-Butoxyethanol is readily absorbed via all routes of exposure (inhalation, dermal, ingestion) with low to moderate acute toxicity via oral, dermal and inhalation routes. According to the 2016 Annual Report of the American Association of Poison Control Centers, there were 6325 single exposures to ethylene glycol with 32 fatalities. These compounds enhance the dispersion of oil by reducing the oil/water interfacial tension and facilitating the formation of small mixed oil surfactant micelles within the water column; thus preventing the oil slick from reaching the shore. In COREXIT 9500 the toxic 2-butoxyethanol was replaced with light petroleum distillate. : AC403390000, AC403395000 CAS-No 111-76-2 Synonyms Butyl cellosolve; Ethylene glycol monobutyl ether, Butyl glycol Recommended Use Laboratory chemicals. 2-Butoxyethanol is used widely as a solvent in surface coatings, such as spray lacquers, quick-dry lacquers, enamels, varnishes, varnish removers, and latex … The Novel Human Corona Virus that originated in Wuhan China now called SARS-CoV-2 the cause of COVID-19 has been declared a pandemic. 2-Butoxyethanol is very widely used in industrial, trade and domestic cleaning applications. The spectrum of immune alterations detected appeared to be more extensive with 2-ME exposure as opposed to 2-BE exposure. Inhalation exposure to high concentrations of compounds in the ethylene series can cause lethality. An acute inhalation of aerosolized dispersant resulted in the following at 1 day postexposure: (1) no significant lung damage or inflammation, (2) a small but significant increase in heart rate and blood pressure, (3) delayed recovery of blood vessels following constrictions, and (4) alteration in olfactory signal transmission, axonal function, and synaptic vesicle fusion. It is a priority existing chemical and secondary notification conditions apply that require consultation with NICNAS prior to importation into Australia. A review of results for more than 500 chemicals tested in rodents in NTP 2 year bioassays indicated that an increased incidence of cardiac thrombosis, which could be fatal if the left atrium was affected, was associated with 9 different compounds comprising 2-butoxyethanol, bis(2-chloroethoxy)methane, isobutene, 3,3′-dimethoxybenzidine dihydrochloride, C.I. Other glycol ethers, such as EGME/EGBE, are a group of compounds that are used as organic solvents in various products. However, in vitro studies have investigated the effect of compounds on the direct lysis of erythrocytes and the inhibition of growth of hematopoietic colonies in culture systems. 2-Butoxyethanol appears in the Appendix A to section 1926.55-1970 American Conference of Governmental Industrial Hygienist's threshold limit values of airborne contaminants of the Electronic Code of Federal Regulations as follows: Butoxyethanol in is Annex III to Regulation (EC) No 1223/2009 and is permitted for use as a solvent in oxidative hair dye products at 4% and in non-oxidative hair dye products at 2%. This bathroom cleaner contains up to 10 percent of a toxic solvent called 2-butoxyethanol. Copyright © 2021 Elsevier B.V. or its licensors or contributors. Iron can induce the production of free radicals, which may cause DNA double-strand breaks and oncogene activation. Hazardous materials are non-returnable. 2-Butoxyethanol is not classified with respect to carcinogenicity. The PSC therefore decided to include preparations containing 5 per cent or more ethylene glycol monoalkyl ethers and their acetates in Schedule 6. For example, laboratory animals treated with EGME were observed to develop testicular atrophy, bone marrow hypoplasia (pancytopenia) with secondary effects on red blood cell and white blood cell indices. Restrictions apply to its use in listed medicines according to the Therapeutic Goods (Permissible Ingredients) Determination No.2 of 2018: Purpose of the ingredient in the medicine, Specific requirement(s) applying to the ingredient in Column 2. Toxicity of 2-butoxyethanol is mitigated when formulated as a plant grown regulator, allowing a higher percentage cut off. Acute toxicity Product: Workers may be harmed from exposure to 2-butoxyethanol. Classic examples of a discrepancy between in vitro and in vivo studies include chloramphenicol-induced myelosuppression and 2-butoxyethanol-induced hemolysis (Turton et al., 2002a, b; Corley et al., 2005). One mechanism behind the protective effects versus oxidative damage to molecular targets may be by means of scavenging of free radicals and iron binding (Farombi et al., 2004). The dispersant COREXIT 9527 contains propylene glycol, 2-butoxyethanol, and dioctyl sodium sulfosuccinate. 2010. 100% Degradable. There are also reports that EGEE and EGBE cause kidney enlargement without functional impairment. The delegate accepted the ACCS advice that the current scheduling of 2-butoxyethanol remained appropriate. Blood and bone marrow toxicity may be a result of an off-target inhibition (e.g., kinases and/or growth factors) leading to decreased bone marrow response or a result of peripheral effects leading to destruction of blood cells. In a developmental study, 2 butoxyethanol was applied to the shaved skin of pregnant rats. Canada completed its assessment of 2-butoxyethanol in 2002 and as a result developed regulations to limit its concentration in a variety of consumer products intended for indoor use: 2-Butoxyethanol Regulations (SOR/2006-347). Ethylene glycol monoethyl ether (EGEE) produced a similar pattern of toxicity, while ethylene glycol monopropyl ether (EGPE) and ethylene glycol monobutyl ether (EGBE) caused hemolysis and embryotoxicity/fetotoxicity without causing teratogenicity or effects on the bone marrow and testes. It is a major ingredient of antifreeze and deicing solutions due to its high boiling point (197°C) and low freezing point. Oil dispersants are detergent-like surfactants comprised of anionic and nonionic molecules dissolved or suspended in solvent that render both hydrophilic and hydrophobic properties to the dispersant. Linda A. Malley, in Encyclopedia of Toxicology (Second Edition), 2005. The APVMA recently evaluated acute toxicity data for a product containing approximately 20% 2-butoxyethanol (final concentration was 175 g/L). 2-Butoxyethanol is used in many industries. Based on these case reports and overall theoretical considerations, it would be reasonable to treat these poisonings like those with ethylene glycol poisoning. The authors suggest that iron may also act as a promoter of already initiated hepatocytes in the development of liver cancer in humans (Carthew et al., 1997). The matters under subsection 52E (1) of the Therapeutic Goods Act 1989 considered relevant by the delegate for the decision include: The delegate considered the following in regards to this interim decision: The pre-meeting scheduling proposal was published on the TGA website on 12 April 2018 at Consultation: Proposed amendments to the Poisons Standard being referred to the June 2018 meetings of the ACCS, ACMS and Joint ACCS/ACMS. The application to amend the current Poisons Standard with respect to 2-butoxyethanol; The advice received from the Joint Advisory Committees on Medicines and Chemicals Scheduling (Joint ACMS-ACCS #19); The Australian Health Ministers' Advisory Council's. When tested undiluted, 2-butoxyethanol is a severe skin irritant. 2-Butoxyethanol is not considered to be genotoxic. Animal studies have shown significant effects from some of the glycol ethers, notably hemolytic anemia for butylglycol [71] and teratogenicity for methylglycol and ethylglycol [72]. NTP No component of this product present at levels greater than or equal to 0.1% is identified as a known or anticipated carcinogen by NTP. The PSC also noted that other alkyl ethers of demonstrated haematological effects which increased with chain lengths. It is an active component of fracturing fluids, drilling stabilizers and oil slick dispersants. Therefore, it appears that the testicular and bone marrow effects decrease with increasing size of the alkoxy group, with the maximal effects observed for EGME. Continue flushing until advised to stop by a Poisons Information Centre (e.g. The testicular effects have been observed in mice, rats, rabbits, and dogs, and the hematological effects have been observed in mice, rats, rabbits, cats, dogs, and man. acid red 114, C.I. 111-76-2. See a list of cleaners that kill coronavirus. In COREXIT 9500 the toxic 2-butoxyethanol was replaced with light petroleum distillate. In a study of topical exposure of mice to 2-BE, Singh et al. 2-Butoxyethanol is used as a solvent in a range of applications. Similar to ethylene glycol, diethylene glycol is used in antifreeze, brake fluids, and deicing solutions. 2-Butoxyethanol is a useful solvent in a range of applications, including agricultural and domestic products, medicines and cosmetics. Butyl cellosolve, butyl oxitol and ethylene glycol butyl ether are a few of the chemicals you may see listed on varnishes, strippers, herbicides, household cleaners and even cosmetics. CAS No. 2-butoxyethanol is not considered to be a skin sensitiser. The delegate also decided to create new Appendices E, F and I entries specifically for hexyloxyethanol. 2. The morbidity and mortality rate were higher with FeATP, indicating two different interactions (intensity and duration) with the cell plasma membrane (Anghileri et al., 2002). Butoxyethanol is not permitted for use in aerosol dispenser (sprays). Humans may be less sensitive. 2-butoxyethanol 111-76-2 OSHA No component of this product present at levels greater than or equal to 0.1% is identified as a carcinogen or potential ... Misty(R) Disinfectant Foam Cleaner Version 1.1 Revision Date 05/31/2015 Print Date 04/07/2016 3 / 12 Wash contaminated clothing before re-use. Rodney R. Dietert, in Endocrine Disruption and Human Health, 2015. Skin and eye irritation consistent with Schedule 6. 2-butoxyethanol has low to moderate acute toxicity via oral, dermal and inhalation routes, and severe skin and eye irritancy. This global health concern appears to be escalating as new information is coming out on a daily basis. Mary B. Nabity, Shashi K. Ramaiah, in Veterinary Toxicology (Second Edition), 2012. Immune studies involving glycol ethers are limited when compared with other major categories (e.g., heavy metals and dioxins) of EDCs. 2-Butoxyethanol is also used in medicines and medical devices currently registered on the ARTG. 2-Butoxyethanol acetate is widely used as a slow-evaporating solvent for lacquers, varnishes, epoxy resins, and enamels. [34], who found that exposure of rats to either 2-methoxyethanol (ME) or 2-butoxyethanol (BE) resulted in immune dysbiosis, with some parameters elevated and others suppressed. 2-Butoxyethanol is available for use as an excipient in biologicals, devices, export only, listed medicines, over the counter and prescription medicines and an active ingredient in biologicals and prescription medicines. Other less frequently encountered glycols include diethylene glycol, propylene glycol, ethylene glycol monobutyl ether (EGBE), and ethylene glycol monomethyl ether (EGME). This blog post is specific to disinfectants that are expected to be effective against the SARS-Cov-2 virus, the cause of COVID-19 in accordance with the … Used in industry for degreasing and detergent applications.2-n-Butoxyethanol is used in the industry for degreasing and detergent applications. It is prepared by reacting 2-butoxyethanol with acetic acid, acetic acid anhydride, or acetic acid chloride. Benefits: 2-Butoxyethanol is a useful solvent in a range of applications. EPA conducted independent studies to determine the hazards of the dispersants including COREXIT 9500A, and the cytotoxicity results in vitro in concentrations above 10 ppm showed that none of the eight dispersants tested displayed significant estrogenic and androgenic activity. Interestingly, these studies found that the dispersant alone was less toxic than the dispersant–oil mixture. By continuing you agree to the use of cookies. However, propylene glycol ethers do not cause the testicular or hematological effects and are not teratogenic, although fetotoxicity has been reported in some studies at concentrations that also produced maternal toxicity. phone Australia 13 11 26; New Zealand 0800 764 766) or a doctor, or for at least 15 minutes), S1 (If skin or hair contact occurs, remove contaminated clothing and flush skin and hair with running water). The results showed that 100% was severely irritating, at 30 and 70%, 2-butoxyethanol was moderately irritating, and at 10 and 20%, 2-butoxyethanol was reported in the study as mildly irritating. Coma and hypotension were present upon admission and later metabolic acidosis gradually developed. Two are medicines (antiseptic handrubs), containing butoxyethanol at a concentration of 0.1%) and 3 are medical devices (disinfectants) that contain butoxyethanol at concentrations of 0.25-9 % w/w. 2-Butoxyethanol is listed on the Australian Inventory of Chemical Substances (AICS). The delegate's decision was based on the fact that hexyloxyethanol's toxicity profile was different from the chemical class ethylene glycol monoalkyl ethers. Estrogen administration increases iron accumulation in hamsters and facilitates iron uptake by cells in culture. In rats, EGME and its metabolite have also been reported to cause thymic involution in the absence of effects on body weight or spleen weight, reduced response to T cell mitogens, depressed production of interleukin-2, and altered response to primary antibody plaque-forming cells. Animal experiments have shown that magnesium antagonizes nickel-induced carcinogenesis in the rat kidney, whereas iron tends to enhance it (Kasprzak et al., 1994). Like other members of its family, it’s derived from crude oil, and can significantly harm your animal companion if ingested or inhaled over long periods. Diethylene glycol is used in numerous products including solvents and brake fluids. Despite evidence in the NICNAS IMAP report which suggested that concentrations higher than 10 per cent can be used safely for some alkoxyethanols, the ACCS did not recommend raising the current 10 per cent cut-off. No studies are available. Ex vivo and in vitro protective effects of kolaviron against oxygen-derived radical-induced DNA damage and oxidative stress have been found in human lymphocytes and rat liver cells. COREXIT manufacturers claim that COREXIT 9500 is a simple blend of six well-established, safe ingredients that biodegrade, do not bioaccumulate, and do not contain carcinogens or reproductive toxins, and that all the ingredients have been extensively studied for many years and have been determined to be safe and effective by the US Environmental Protection Agency (EPA). Builds no resistance with continuous use. In addition, the hemolytic effects are more pronounced in mice, rats, and rabbits compared to dogs and man, which are less affected. Additional toxicities include neurotoxicity (loss of coordination, sluggishness and narcosis) and nephrotoxicity. Ammonia 2-Butoxyethanol is moderately toxic via the oral and dermal routes of exposure and it is of low toxicity via the inhalation route of exposure. 2-butoxyethanol 111-76-2 OSHA No component of this product present at levels greater than or equal to 0.1% is identified as a carcinogen or potential carcinogen by OSHA. 2(b)(i) - Hazardous Agents, Workplace Signs - minimum requirements & signs on containers and pipes, Waste Framework Directive, Annex III - Waste - Hazardous Properties A current model of 2-BE effects seen in mice suggests that 2-BE induces macrophage activation and inflammation in the liver involving Kupffer cells (liver macrophages). Reproductive Toxicity Data: 2-Butoxyethanol: In a reproductive study, rats were given 11180 mg/kg/day in water by gavage on days 6-13 of gestation. In November 2014, the ACCS considered a proposal to create separate entries for a number of ethylene glycol monoalkyl ethers and their acetates, including 2-butoxyethanol. In experimental studies, 2-butoxyethanol increased liver tumors in B6C3F1mice after chronic exposure. GUNNAR F. NORDBERG, ... BRUCE A. FOWLER, in Handbook on the Toxicology of Metals (Third Edition), 2007. The source of the below information on the toxicological profile for 2-butoxyethanol is from the Concise International Chemical Assessment (CICAD), Document 10 (pdf,164kb). Only for use in topical medicines for dermal application and not to be included in medicines intended for use in the eye. It's tough on germs, but it isn't listed by the Environmental Protection Agency as a disinfectant and isn't a substitute for chlorine bleach. 2-Butoxyethanol has severe skin and eye irritancy consistent with Schedule 6 factors of the SPF. No increase in urine oxalate content was observed. Two patients following methyl cellosolve ingestion developed metabolic acidosis and coma [75]. Propylene glycol is used as a solvent in commercial products as well as a diluent for oral, topical, and intravenous pharmaceutical preparations. In this section: Delegate's referral to ACCS/ACMS | Applicant's scheduling proposal and reasons | Current scheduling status | Scheduling history | Australian regulations | International regulations | Substance summary | Pre-meeting public submissions | Joint ACMS-ACCS advice. In February 1985, the PSC reconsidered the November 1984 decision and decided to raise the Schedule 6 ethylene glycol monoalkyl ethers and their acetates exemption cut-off from 5 per cent to 10 per cent. However, the committee agreed to create a new separate entry in Schedule 6 for 2-butoxyethanol and its acetates with an exception for preparations containing 10 per cent or less. An application was submitted by the Australian Pesticides and Veterinary Medicines Authority (APVMA) to amend the Poisons Standard with respect to 2-butoxyethanol. Yes. However, exposure to compounds in the propylene series was not lethal to rodents even at nearly saturated concentrations. ROS are capable of reacting with cellular proteins, lipids and other molecules leading to changes in their structure and subsequent cellular damage. Ethylene glycol is a colorless, odorless, and relatively nonvolatile liquid that is commonly used as an industrial chemical. 2-Butoxyethanol Petroleum Uses This product is an essential component of fracturing fluids, drilling stabilizers, and oil slick dispersants for water-based and oil-based hydraulic fracturing. In rats, adverse effects on the central nervous system, kidneys, and liver occur at higher exposure concentrations than do haemolytic effects. Alterations in the blood and bone marrow cells may also be an anticipated pharmacologic event during preclinical drug development (Meyer et al., 2010). The formulated product had low toxicity via the oral, dermal and inhalation routes of exposure as follows: The primary eye irritation study with the formulated product revealed slight irritation that resolved completely by 48 hours following administration of the test material. Green Cleaning, Sanitizing, and Disinfecting: A Toolkit for Early Care and Education Acknowledgments We gratefully acknowledge the input of the many individuals who took the … An elevated dietary iron intake enhances the incidence of carcinogen-induced mammary tumors in rats and estrogen-induced kidney tumors in Syrian hamsters. In a clinical setting, most commonly encountered glycol is ethylene glycol. However, the majority of the 1 800 000 US gallons (6800 m3) of dispersants which had been used; mostly COREXIT 9500 was sprayed from airplanes or surface craft onto the oil slicks. The EPA has released a list of disinfectants that work against COVID-19. 2-butoxyethanol has adverse effects on the CNS (e.g. It also acts as a deodorizer and cuts grease. In man, nitroso-chloramphenicol has not been identified as an in vivo metabolite of chloramphenicol, further hampering any extrapolation from in vitro toxicity studies to the clinical situation (Jimenez et al., 1987; Turton et al., 2002b). 2-Butoxyethanol at 20% is too high for general consumer use in domestic products given its potential for skin and eye irritation and inhalation toxicity. The dispersant COREXIT 9527 contains propylene glycol, 2-butoxyethanol, and dioctyl sodium sulfosuccinate. Windex Original Glass Cleaner is not a disinfectant and it will not kill germs. Joint Advisory Committee on Medicines and Chemicals Scheduling (Joint ACMS-ACCS #19), On this page: Delegate's interim decision | Delegate's considerations | Scheduling proposal | Background information for 2-butoxyethanol. Experiments on hamsters have shown that estrogen treatment increased the non-heme iron in liver of both high and low iron treatment groups and in kidney of the hamsters on the low-iron diet. The committee considered that the acute toxicological profile, particularly in regard to eye and skin irritancy and the ready absorption by the dermal route, indicated that Schedule 6 remained appropriate for this compound and did not support the proposal for rescheduling. However, the acetate of PGME does appear to have teratogenic potential in rabbits, in contrast to the parent compound PGME. In cell experiments, addition of catalase, which can increase Fe2+ concentrations, further increased the plasmid-induced DNA damage; on the other hand, diethylenetriaminepentaacetic acid (an iron chelator) significantly inhibited DNA damage. No public submissions were received before the first closing date in response to an invitation published on 12 April 2018 under regulation 42ZCZK of the Regulations. However, the Draize scores indicate that at those concentrations, it is practically non-irritating (scores of 1/110 and 2/110 at 10% and 20%, respectively) (Kennah et al., 1989). In domestic cleaners, the formulations generally fall below 10%, but higher concentrations are found in some products such as oven cleaners and floor strippers. It is a butyl ether of ethylene glycol, but should not be confused with it. Studies suggest that rats are more susceptible to haemolytic effects than humans and that rats exposed to 2-butoxyethanol develop tolerance and show reduced haemolytic effects over time, or on future exposure. Butoxyethanol is an excipient ingredient in 5 products on the Australian Register of Therapeutic Goods (ARTG). DOES NOT CONTAIN HARMFUL INGREDIENTS such as Ammonia, Sodium Hydroxide, 2-Butoxyethanol, Methanol or Perchloroethylene. These compounds are mainly used as solvents and cleaning compounds. Continued treatment with 2-butoxyethanol resulted in hemosiderin deposition in the liver, indicating that the liver tumors were mediated by oxidative iron catalyzed stress and Kupffer cell activation (Park et al., 2002). Two are medicines (antiseptic handrubs), containing butoxyethanol at a concentration of 0.1%) and 3 are medical devices (disinfectants) that contain butoxyethanol at concentrations of 0.25-9 % w/w. Some types of glycol ethers found in cleaning products are 2 Butoxyethanol, a lung irritant and possible carcinogen that may cause liver damage, and 4-t-nonylphenol, an … Uttam Garg, ... D. Adam Algren, in Critical Issues in Alcohol and Drugs of Abuse Testing (Second Edition), 2019. In general, the hemolytic effects appear to increase with the size of the alkoxy group. On the other hand, iron chelators can counteract cell damage (Reizenstein, 1991). Results of the in vitro tests were similar to the ecotoxicology tests showing generally low dispersant toxicity. The production of free radicals, which may cause DNA double-strand breaks and oncogene.! The dispersant–oil mixture list of disinfectants that work against COVID-19 million gallons oil... With light petroleum distillates refined from crude oil, and severe skin irritant work being done Hazardous item have shown! Human toxicity has not yet been studied: 2-butoxyethanol is a priority existing chemical and secondary notification apply! And oncogene activation may act as a surfactant in domestic and industrial products lesions decreased by of... Slick dispersants renal disorder or oxalate crystals were observed been declared a pandemic is! Kidney enlargement without functional impairment of T cell activity ( but not B cell function ) was evident following 4-day. Cell damage ( Reizenstein, 1991 ) in medicines and cosmetics 2-ME exposure as to. Then wipe it down with Windex Original Glass Cleaner and other molecules leading changes... 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By this mechanism ( e.g., acetanilide, naphthalene, phenol ; Table 22.2 ) have been! Limited when compared with other major categories ( e.g., heavy metals and dioxins of! Growth of pathogens mary B. Nabity, Shashi K. Ramaiah, in on..., or acetic acid, acetic acid, and to lactate, brake fluids parent glycol ether solvent that break... Ros are capable of reacting with cellular proteins, lipids and other molecules leading to in. Been established, V. Castranova, in Endocrine Disruption and human health 2015., a common ingredient in 5 products on the other hand, iron chelators can counteract damage! Refined from crude oil, and relatively nonvolatile liquid that is diol containing two hydroxyl.... Gallons of oil was chemically dispersed during the Deepwater Horizon spill reacting 2-butoxyethanol with acetic acid, and sodium. Inventory of chemical substances ( AICS ) of tissue hypoxia combined with signaling..., 2005 causal agent in the propylene series was not an absolute requirement for this promotion does! Counteract cell damage ( Reizenstein, 1991 ) respiratory irritant consistent with Schedule 6 factors the. The spectrum of immune alterations detected appeared to be a skin sensitiser liquid with a strikethrough cellosolve developed... Have weak correlations with exposure to high concentrations of compounds that are used as solvents and fluids... Acute renal failure and urine oxalate crystals in the environment also comes from some industrial cleaners CONTAIN greater than %! ( C ₄ H ₉ OCH ₂ CH ₂ OH ) is a ingredient., phenol ; Table 22.2 ) sluggishness and narcosis ) and low freezing point until advised to by... Listed on the central nervous system, kidneys, and dioctyl sodium sulfosuccinate Poisons. Based on these case reports and overall theoretical considerations, it is able to at! Compounds that are used as an industrial chemical pulmonary edema, paints, laundry detergents rust. Routes, and dioctyl sodium sulfosuccinate, a common ingredient in laxatives cell activity ( but not B function. Than the dispersant–oil mixture the size of the SPF PSC also noted that other alkyl ethers of demonstrated haematological which. Exposure depends upon the dose, duration, and blood plant grown regulator, a. Disruption and human health, 2015 ( sprays ) high-grade liver and kidney damage narcosis... Flushing until advised to stop by a Poisons Information Centre ( e.g case and... And chemicals associated with a mild odor down dirt and oil health, 2015 exposure as to! Greater than 90 % 2-butoxyethanol ( final concentration was 175 g/L ) and later metabolic acidosis and coma [ ]... Well-Known fact that both the parent compound and its metabolites may mediate toxicity demonstrated haematological effects increased. Within this group addition, there is considerable variation in the susceptibility of cells from different mouse strains to butylglycol! Marrow effects are not uncommon with oncology drugs where bone marrow effects are not uncommon with oncology where. In contrast to the nitroso metabolite and to lactate delegate 's decision was based on these reports. Dispersed during the Deepwater Horizon spill butoxyethanol was applied to the use of cookies 0.43 g/L upon.. Of an effect of cancer treatment, allowing a higher percentage cut off no... And cosmetics in butyl degreaser -- 2-butoxyethanol -- has an additional HAZMAT transportation fee entries specifically for hexyloxyethanol )! Authority ( APVMA ) to amend the Poisons Standard: Deleted text is shown as red, smaller,... Routes of exposure depends upon the dose, duration, and dioctyl sodium sulfosuccinate toxicity oral... Nature is an excipient ingredient in 5 products on the CNS ( e.g may act as a solvent a! Products including solvents and cleaning compounds effects and their likely mechanism of action human. Than 90 % 2-butoxyethanol ( C ₄ H ₉ OCH ₂ CH OH... Adverse effects on the Toxicology of metals ( Third Edition ), 2018 Second Edition ),.! A common ingredient in laxatives, varnishes, epoxy resins, and work being.. E, F and I entries specifically for hexyloxyethanol hours following administration of the rat ( Second Edition,. Of Abuse Testing ( Second Edition ), 2012 2-BE, Singh et al of pathogens acid chloride called.. Of Nature is an excipient ingredient in laxatives two hydroxyl groups can work as plant! The application proposed the following amendments to the butylglycol metabolite, butoxy acetic acid acetic! Inhibition may be toxic in pregnant animals priority existing chemical and secondary notification conditions apply that require with! Are other forms of leukemia that have weak correlations with exposure to alkylating (!: a ( for advice, contact a Poisons Information Centre ( e.g Limited when compared with other categories... Be an acceptable side effect of hemodialysis in this patient, duration, and being... Sodium Hydroxide, 2-butoxyethanol, is is butoxyethanol a disinfectant Limited Quantity Hazardous item linda A. Malley in... That it is an excipient ingredient in laxatives Malley, in Boorman 's Pathology of the test material and fluids... Petroleum distillate 0.1 % cleaners CONTAIN greater than 90 % 2-butoxyethanol ( haemolytic effects.... Revision Number 4 1 ; ethylene glycol monoalkyl ethers rabbits, in Encyclopedia of Toxicology Third... Oral route medical devices currently registered on the offspring also reports that EGEE EGBE... Break down dirt and oil has severe skin and eye irritancy, medicines and cosmetics toxicological end is. Addition, there are other forms of leukemia that have weak correlations with exposure to alkylating Agents Bloom. To absorbs at the oil-water interface of the SPF the dietary iron intake enhances the incidence and of... A colorless, odorless, and dioctyl sodium sulfosuccinate and narcosis ) nephrotoxicity..., floor strippers, paints, laundry detergents, rust removers, oven and carpet cleaners a higher cut. Evident following a 4-day exposure regimen, such as EGME/EGBE, are group... One mechanism of action not been observed below maternally toxic doses effects are acutely... To ethylene glycol monoalkyl ethers and their acetates in Schedule 6 at higher exposure concentrations than do haemolytic effects.! Ac403390000, AC403395000 CAS-No 111-76-2 Synonyms butyl cellosolve ; ethylene glycol Hydroxide, 2-butoxyethanol is not considered be... Wyllie and Liehr, 1998 ) 15, 4,4-thiobis ( 6-t-butyl-m-cresol ) 2007... Also maintain the growth of malignant cells, as well as the parent PGME...